Hydrochloric Acid → 4-(1H-pyrazol-3-yl)aniline

Participants

Reaction Steps

To a solution of 5-(4-nitrophenyl)pyrazole (10.1 g) in ethanol (100 ml) was added Tin(II) chloride dihydrate (35.7 g) and concentrated hydrochloric acid (25.5 ml). After the addition was completed, the reaction mixture was refluxed for 3 hours. After cooling, the solvent was evaporated and strongly basified (NaOH solution) and then extracted with chloroform. The extract was washed with brine, dried (MgSO4) and evaporated to dryness to obtain the title compound (8.1 g).

Provenance & Evidence