3-Chloro-1-propyne → HCID 18323800, compound

HRID 1251477Notes

Reaction equation

HRID 1251477 reaction equation
[Br:1][C:2]1[CH:16]=[C:15]([CH:17]([CH3:19])[CH3:18])[CH:14]=[CH:13][C:3]=1[NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[N:6]=1.[CH2:20](Cl)[C:21]#[CH:22]>>[Br:1][C:2]1[CH:16]=[C:15]([CH:17]([CH3:19])[CH3:18])[CH:14]=[CH:13][C:3]=1[N:4]([CH2:22][C:21]#[CH:20])[C:5]1[N:6]=[C:7]([CH3:12])[CH:8]=[C:9]([CH3:11])[N:10]=1

Participants

3

Reactant 2

HCID 122213-Chloro-1-propyneHCID 10591763HCID 10591763, compound

Product 1

HCID 18323800HCID 18323800, compound

Procedure

By using 2-(2-bromo-4-(1-methylethyl)anilino)-4,6-dimethylpyrimidine and substituting propargyl chloride in Example 9, the title compound was isolated as the free-base, Mass spec. (NH3-CI/DDIP): 358 (M+H)+.

Sources & evidence

ORD record
ord-7288505322974b048d6aafb05588882d
Source dataset
uspto-grants-2002_01
Patent number
US06342503B1

Reaction notes

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