Acetic Anhydride → HCID 22258036, compound

HRID 1251590Notes

Reaction equation

HRID 1251590 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C:9]1[CH:10]=[C:11]([S:15][C:16]2[C:24]3[C:23](=[O:25])[N:22]([CH3:26])[C:21](=[O:27])[N:20]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:19]=3[S:18][C:17]=2[CH2:32][C:33]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH:36]=[CH:35][CH:34]=2)[CH:12]=[CH:13][CH:14]=1.C(N(CC)CC)C>ClCCl>[C:1]([NH:8][C:9]1[CH:10]=[C:11]([S:15][C:16]2[C:24]3[C:23](=[O:25])[N:22]([CH3:26])[C:21](=[O:27])[N:20]([CH2:28][CH:29]([CH3:30])[CH3:31])[C:19]=3[S:18][C:17]=2[CH2:32][C:33]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH:36]=[CH:35][CH:34]=2)[CH:12]=[CH:13][CH:14]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 22258012HCID 22258012, compound

Product 1

HCID 22258036HCID 22258036, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetic anhydride (0.034 ml) was added to a solution of 5-[(3-aminophenyl)thio]-3-methyl-1-(2-methylpropyl)-6-(1-naphthalenylmethyl) thieno[2,3-d]pyrimidine-2,4-(1H, 3H)-dione (60 mg) and triethylamine (0.067 ml) in anhydrous dichloromethane (2 ml) at room temperature. After 1 hour, work-up and purification as in Example 32 gave the title compound (15 mg).

Workup

  1. customwork-up and purification as in Example 32

Sources & evidence

ORD record
ord-055b60ff2981404db23f7214e6f60c3c
Source dataset
uspto-grants-2002_01
Patent number
US06342502B1

Reaction notes

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