Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Kasugamycin hydrochloride | HCID 88045 | — |
| Reactant | Potassium Permanganate | HCID 516875 | — |
| Reactant | HCID 178461616 | HCID 178461616 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | An inositol | HCID 892 | 20% |
Reaction Steps
Kasugamycin hydrochloride (1 g) and 2N trifluoroacetic acid (5 mL) were combined and heated 4 h at 75° C., after which time silica gel TLC (solvent-butanol:acetic acid:water, 2:1:1; Visualization with potassium permanganate stain showed kasugamycin was still present. The solution was concentrated in vacuo. The hydrolysis product was purified in the usual manner using ion exchange resins and charcoal. D-chiro-inositol was obtained in 20% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06342645B2 |
|---|
| Source dataset | uspto-grants-2002_01 |
|---|
| ORD ID | ord-22c68d8a58114f49bdd71a6662b758c7 |
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| Source note | uspto-grants-2002_01 |
|---|
