Dimethylformamide → 2-Ethyl-5-methylbenzo[b]thiophene-3-sulfonylchloride

反応式

CN(C=O)C.[S:6]([Cl:10])(Cl)(=[O:8])=[O:7].[CH2:11]([C:13]1[S:17][C:16]2[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:15]=2[CH:14]=1)[CH3:12]>>[CH2:11]([C:13]1[S:17][C:16]2[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:15]=2[C:14]=1[S:6]([Cl:10])(=[O:8])=[O:7])[CH3:12]

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 24648Sulfuryl chloride

HCID 5953442-Ethyl-5-methylbenzo[b]thiophene

生成物 1

HCID 229984372-Ethyl-5-methylbenzo[b]thiophene-3-sulfonylchloride

実験手順

2-ethyl-5-methylbenzo[b]thiophene-3-sulfonylchloride was prepared in the same manner as described in Example 40B. Reaction of DMF (6.5 mmoles, 0.50 ml), sulfurylchloride (5.5 mmoles, 0.44 ml) and 2-ethyl-5-methylbenzo[b]thiophene (3.2 mmoles, 0.57 g) yielded, after flash chromatography, using 2% ethyl acetate/hexanes, 0.58 g (66%) of an orange solid.

後処理

customyielded

出典と根拠

ORDレコード: ord-d9f3b05173a5494aac37490f028e3aaf
出典データセット: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06342610B2

反応ノート

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