HRID1251874

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7010638

未命名化合物

结构：O=C(O)c1ccc(C(OCCn2ccnc2)c2nccs2)cc1-c1ccc(F)cc1

HCID18324473

未命名化合物

PRODUCTS

生成物

结构：CSCC[C@H](NC(=O)c1ccc(C(OCCn2ccnc2)c2nccs2)cc1-c1ccc(F)cc1)C(=O)OC(C)(C)C

HCID86585134

未命名化合物

收率 63%

PROCEDURE

实验过程

The title compound was prepared from 2-(4-fluorophenyl)4-[1-(thiazol-2-yl)-2-(imidazol-1-yl)ethoxymethyl]benzoic acid by a similar method to that used for Example 1 but using L-methionine tert-butyl ester in place of L-methionine methyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af1cc7d61edd4d6bbd6c2f6ecc105e19
来源数据集: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06342765B1
来源说明: uspto-grants-2002_01

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]([CH:17]([O:23][CH2:24][CH2:25][N:26]3[CH:30]=[CH:29][N:28]=[CH:27]3)[C:18]3[S:19][CH:20]=[CH:21][N:22]=3)[CH:14]=[CH:13][C:9]=2[C:10]([OH:12])=O)=[CH:4][CH:3]=1.[C:31]([O:35][C:36](=[O:43])[C@H:37]([CH2:39][CH2:40][S:41][CH3:42])[NH2:38])([CH3:34])([CH3:33])[CH3:32]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]([CH:17]([O:23][CH2:24][CH2:25][N:26]3[CH:30]=[CH:29][N:28]=[CH:27]3)[C:18]3[S:19][CH:20]=[CH:21][N:22]=3)[CH:14]=[CH:13][C:9]=2[C:10]([NH:38][C@@H:37]([CH2:39][CH2:40][S:41][CH3:42])[C:36]([O:35][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:43])=[O:12])=[CH:4][CH:3]=1