HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl (2S)-2-amino-4-(methylsulfanyl)butanoate → Tert-butyl (2S)-2-{2-(4-fluorophenyl)-4-[1-(thiazol-2-yl)-2-(imidazol-1-yl)ethoxymethyl]benzoylamino}-4-methylsulfanylbutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl (2S)-2-amino-4-(methylsulfanyl)butanoate | HCID 7010638 | — |
| Reactant | 2-(4-Fluorophenyl)-4-[1-(thiazol-2-yl)-2-(imidazol-1-yl)ethoxymethyl]benzoic acid | HCID 18324473 | — |
| Product | Tert-butyl (2S)-2-{2-(4-fluorophenyl)-4-[1-(thiazol-2-yl)-2-(imidazol-1-yl)ethoxymethyl]benzoylamino}-4-methylsulfanylbutyrate | HCID 86585134 | 63% |
Reaction Steps
The title compound was prepared from 2-(4-fluorophenyl)4-[1-(thiazol-2-yl)-2-(imidazol-1-yl)ethoxymethyl]benzoic acid by a similar method to that used for Example 1 but using L-methionine tert-butyl ester in place of L-methionine methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342765B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-af1cc7d61edd4d6bbd6c2f6ecc105e19 |
| Source note | uspto-grants-2002_01 |