反应详情

A solution of tert-butyl (2S)-2-{-5-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoylamino}-4-methylsulfonylbutyrate, (88 mg, 0.13 mmol) in TFA (2 ml), was stirred and cooled in an ice-bath for 3 hours. The TFA was removed by evaporation, the residue was dissolved in ethyl acetate and 1M HCl/diethylether (5 ml). Removal of the solvent gave a brown oil which on trituration with diethylether/iso-hexane (3×) gave the HCl salt of the title compound as a sticky white solid (40 mg).

1. temperaturecooled in an ice-bath for 3 hours
2. customThe TFA was removed by evaporation
3. dissolutionthe residue was dissolved in ethyl acetate
4. customRemoval of the solvent