Sodium Hydroxide → 5-[1-(Thiazol-2-yl)-2-(imidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid

HRID 1251898Notes

Reaction equation

HRID 1251898 reaction equation
[N:1]1([CH2:6][CH:7]([C:28]2[S:29][CH:30]=[CH:31][N:32]=2)[O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[C:13]([CH:18]=2)[C:14]([O:16]C)=[O:15])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Na+]>>[N:1]1([CH2:6][CH:7]([C:28]2[S:29][CH:30]=[CH:31][N:32]=2)[O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)=[C:13]([CH:18]=2)[C:14]([OH:16])=[O:15])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18324507Methyl 5-[2-(imidazol-1-yl)-1-(thiazol-2-yl)ethoxy]-2-(4-fluorophenethyl)benzoate

Product 1

HCID 183244285-[1-(Thiazol-2-yl)-2-(imidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid

Procedure

Methyl 5-[2-(imidazol-1-yl)-1-(thiazol-2-yl)ethoxy]-2-(4-fluorophenethyl)benzoate was hydrolysed using aqueous sodium hydroxide solution to give 5-[2-(imidazol-1-yl)-1-(thiazol-2-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid.

Sources & evidence

ORD record
ord-9433cc22802745aca9e7b1a17d4b6231
Source dataset
uspto-grants-2002_01
Patent number
US06342765B1

Reaction notes

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