HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-[1-(4-Fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoate | HCID 18324372 | — |
| Product | 5-[1-(4-Fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid | HCID 18324391 | 45.2% |
Reaction Steps
Methyl 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoate (4.2 g, ˜8.8 mmol) was hydrolysed with aqueous sodium hydroxide solution under the usual conditions to give 5-[1-(4-fluorophenyl)-2-(2-methylimidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid (1.84 g, ˜45% ) as a colourless gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342765B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-d61e547e760746fdb39dd245629a423c |
| Source note | uspto-grants-2002_01 |