Isopropyl Acetate → HCID 20140571, compound

Participants

Reaction Steps

100 g of silica gel are added to a solution of 200 g of 3-isopropyl-3-methyl-2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5(3H)-dione in 900 ml of isopropyl acetate and 100 ml of absolute isopropanol, and the resulting suspension is then stirred at room temperature for about 16 hours. The mixture is subsequently filtered, the filtrate is evaporated to dryness and the residue is crystallized from ethyl acetate/n-hexane. There is obtained 1,9b-dihydro-9b-isopropoxy-3-isopropyl-3-methyl-2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5(3H)-dione as colorless crystals, m.p. 158°-160° C.

Provenance & Evidence