Isopropyl Acetate → HCID 20140571, compound

HRID 1251941Notes

Reaction equation

HRID 1251941 reaction equation
[CH:1]([C:4]1([CH3:18])[N:8]2[C:9](=[O:16])[C:10]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[C:7]2=[N:6][C:5]1=[O:17])([CH3:3])[CH3:2].C([O:22][CH:23]([CH3:25])[CH3:24])(=O)C>C(O)(C)C>[CH:23]([O:22][C:7]12[NH:6][C:5](=[O:17])[C:4]([CH:1]([CH3:3])[CH3:2])([CH3:18])[N:8]1[C:9](=[O:16])[C:10]1[C:11]2=[N:12][CH:13]=[CH:14][CH:15]=1)([CH3:25])[CH3:24]

Participants

4

Reactant 2

HCID 7915Isopropyl AcetateHCID 13246864HCID 13246864, compound

Product 1

HCID 20140571HCID 20140571, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

100 g of silica gel are added to a solution of 200 g of 3-isopropyl-3-methyl-2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5(3H)-dione in 900 ml of isopropyl acetate and 100 ml of absolute isopropanol, and the resulting suspension is then stirred at room temperature for about 16 hours. The mixture is subsequently filtered, the filtrate is evaporated to dryness and the residue is crystallized from ethyl acetate/n-hexane. There is obtained 1,9b-dihydro-9b-isopropoxy-3-isopropyl-3-methyl-2H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5(3H)-dione as colorless crystals, m.p. 158°-160° C.

Workup

  1. filtrationThe mixture is subsequently filtered
  2. customthe filtrate is evaporated to dryness
  3. customthe residue is crystallized from ethyl acetate/n-hexane

Sources & evidence

ORD record
ord-a506eb6bb64d4b9eb84dfd2dc7c28421
Source dataset
uspto-grants-1988_05
Patent number
US04741767

Reaction notes

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