Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide

HRID 1252023Notes

Reaction equation

HRID 1252023 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:9])=[C:6]([OH:8])[CH:7]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(#N)C>[C:10]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:9])=[C:6]([OH:8])[CH:7]=1)(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 806765-Amino-2-chlorophenol

Product 1

HCID 14122483N-(4-Chloro-3-hydroxyphenyl)acetamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension containing 80 g (0.56 mole) of 5-amino-2-chlorophenol, 70 ml (0.74 mole) of acetic anhydride, and 200 ml of acetonitrile was refluxed with stirring for 2 hours. This suspension was cooled to room temperature and the resulting crystalline precipitate was collected by filtration and washed with 200 ml of acetonitrile.

Workup

  1. temperaturewas refluxed
  2. filtrationthe resulting crystalline precipitate was collected by filtration
  3. washwashed with 200 ml of acetonitrile

Sources & evidence

ORD record
ord-a2be6703791445f9ba32dec24617d8ed
Source dataset
uspto-grants-1988_05
Patent number
US04741997

Reaction notes

Loading…