HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-Amino-2-chlorophenol | HCID 80676 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(4-Chloro-3-hydroxyphenyl)acetamide | HCID 14122483 | — |
Reaction Steps
A suspension containing 80 g (0.56 mole) of 5-amino-2-chlorophenol, 70 ml (0.74 mole) of acetic anhydride, and 200 ml of acetonitrile was refluxed with stirring for 2 hours. This suspension was cooled to room temperature and the resulting crystalline precipitate was collected by filtration and washed with 200 ml of acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04741997 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-a2be6703791445f9ba32dec24617d8ed |
| Source note | uspto-grants-1988_05 |