反应详情

To a mixture of 2-amino-4-chloromethylthiazole hydrochloride (2 g), anhydrous pyridine (3.2 g) and anhydrous N,N-dimethylformamide (10 ml) was slowly added acetic formic anhydride (1.7 g) with stirring at 0° to 5° C. After one hour of stirring, the reaction mixture was poured into cold water and extracted with ethyl acetate. The extract was washed with 1N hydrochloric acid and aqueous sodium chloride solution successively and dried over magnesium sulfate. The solvent was then distilled off and the residue was collected and dried to give 2-formylamino-4-chloromethylthiazole (0.94 g).

1. stirringAfter one hour of stirring
2. extractionextracted with ethyl acetate
3. washThe extract was washed with 1N hydrochloric acid and aqueous sodium chloride solution successively
4. dry with materialdried over magnesium sulfate
5. distillationThe solvent was then distilled off
6. customthe residue was collected
7. customdried