反应详情

Mass (m/e): 214 (M30) . (2) A mixture of 2-acetylamino-4-acetoxymethylthiazole (72 g), potassium carbonate (23.2 g), methanol (1.1 l) and water (0.1 l) was stirred for 3 hours and 20 minutes at ambient temperature. An insoluble material was filtered off and the filtrate was neutralized with 2N hydrochloric acid and evaporated. To the residue was added a mixture of chloroform and methanol (100 ml, 1:1 V/V) and the mixture was heated. An insoluble material was filtered off and the filtrate was concentrated. The residue was purified by column chromatography on silica gel eluting with a mixture of chloroform and methanol (10:1 V/V) to give 2-acetylamino-4-hydroxymethylthiazole (41.11 g).

1. filtrationAn insoluble material was filtered off
2. customevaporated
3. additionTo the residue was added
4. additiona mixture of chloroform and methanol (100 ml, 1:1 V/V)
5. temperaturethe mixture was heated
6. filtrationAn insoluble material was filtered off
7. concentrationthe filtrate was concentrated
8. customThe residue was purified by column chromatography on silica gel eluting with a mixture of chloroform and methanol (10:1 V/V)