(Triphenylphosphoranylidene)acetaldehyde → HCID 54042463, compound

HRID 1252062Notes

Reaction equation

HRID 1252062 reaction equation
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH:10]=O)[N:9]=1)(=[O:3])[CH3:2].[CH:12]([CH:14]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:13]>C(Cl)(Cl)Cl>[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH:10]=[CH:14][CH:12]=[O:13])[N:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 75051(Triphenylphosphoranylidene)acetaldehydeHCID 14931749N-(4-Formyl-1,3-thiazol-2-YL)acetamide

Product 1

HCID 54042463HCID 54042463, compoundYield 64.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixtuxe of 2-acetylamino-4-formylthiazole (6.05 g), formylmethylidenetriphenylphosphorane (10.82 g) and chloroform (360 ml) was refluxed for 4 hours. The precipitates were collected by filtration and washed with chloroform to give 2-acetylamino-4-(2-formylvinyl)thiazole (4.52 g).

Workup

  1. filtrationThe precipitates were collected by filtration
  2. washwashed with chloroform

Sources & evidence

ORD record
ord-205a10bdd6cd4bc59f2e55e7716fc15f
Source dataset
uspto-grants-1988_05
Patent number
US04742057

Reaction notes

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