反应详情

温度

80 °C

2-Acetylamino-4-[4-(3-indolyl)piperidinomethyl]thiazole (1.2 g) in a mixture of ethanol (3 ml) and 10% hydrochloric acid (9 ml) was stirred at 80° C. for 2.5 hours. After cooling to ambient temperature, the reaction mixture was concentrated under reduced pressure. To the residue was added dropwise 10% aqueous sodium hydroxide solution (12 ml) under ice-cooling. The resulting crystals were collected, washed with water, dried and recrystallized from ethanol to give 2-amino-4-[4-(3-indolyl)piperidinomethyl]thiazole (410 mg).

1. temperatureAfter cooling to ambient temperature
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionTo the residue was added dropwise 10% aqueous sodium hydroxide solution (12 ml) under ice-
4. temperaturecooling
5. customThe resulting crystals were collected
6. washwashed with water
7. customdried
8. customrecrystallized from ethanol