Hydrochloric Acid → HCID 20140941, compound

HRID 1252082Notes

Reaction equation

HRID 1252082 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[N:19]=[C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])[S:21][CH:22]=3)[CH2:12][CH2:11]2)=[CH:2]1.[ClH:28]>C(O)C>[ClH:28].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[N:19]=[C:20]([NH:23][S:24]([CH3:27])(=[O:25])=[O:26])[S:21][CH:22]=3)[CH2:12][CH2:11]2)=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14129818HCID 14129818, compound

Product 1

HCID 20140941HCID 20140941, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

In hot ethanol (80 ml) was dissolved 4-[2-[4-(3-indolyl)piperidino]ethyl]-2-mesylaminothiazole (0.5 g). After the solution was cooled to ambient temperature, 15% solution of hydrogen chloride in ethanol (3 ml) was added, followed by cooling to 5° C. The resulting precipitate was collected by filtration and washed with ethanol. This precipitate was recrystallized from water (50 ml) to give 4-[2-[4-(3-indolyl)piperidino]ethyl]-2-mesylaminothiazole hydrochloride (0.42 g).

Workup

  1. temperatureby cooling to 5° C
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with ethanol
  4. customThis precipitate was recrystallized from water (50 ml)

Sources & evidence

ORD record
ord-e72f11106f1a4484857758d4f2704f26
Source dataset
uspto-grants-1988_05
Patent number
US04742057

Reaction notes

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