Hydroxyamine hydrochloride → HCID 86742146, compound

Participants

Reaction Steps

A suspension of 88.31 g of 8-bromo-1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10[2H,5H]-dione in 95% ethanol (550 ml) was treated with a premixed solution of 85.73 g of sodium acetate trihydrate in water (300 ml) and 43.78 g of hydroxylamine hydrochloride in water (300 ml). The solution was refluxed for 2 hours. The reaction mixture was then cooled to room temperature at which time a precipitate began to separate from the mixture. The precipitate was isolated by vacuum filtration.

Provenance & Evidence