Hydroxyamine hydrochloride → HCID 86742146, compound

HRID 1252116Notes

Reaction equation

HRID 1252116 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[CH2:8][N:7]3[C:12](=O)[CH2:13][CH2:14][CH:6]3[C:5](=[O:16])[C:4]=2[CH:3]=1.[OH2:17].O.O.C([O-])(=O)C.[Na+].Cl.[NH2:26]O>C(O)C.O>[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[CH2:8][N:7]3[C:12](=[N:26][OH:17])[CH2:13][CH2:14][CH:6]3[C:5](=[O:16])[C:4]=2[CH:3]=1

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 13150086HCID 13150086, compoundHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 86742146HCID 86742146, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

A suspension of 88.31 g of 8-bromo-1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10[2H,5H]-dione in 95% ethanol (550 ml) was treated with a premixed solution of 85.73 g of sodium acetate trihydrate in water (300 ml) and 43.78 g of hydroxylamine hydrochloride in water (300 ml). The solution was refluxed for 2 hours. The reaction mixture was then cooled to room temperature at which time a precipitate began to separate from the mixture. The precipitate was isolated by vacuum filtration.

Workup

  1. temperatureThe solution was refluxed for 2 hours
  2. customto separate from the mixture
  3. customThe precipitate was isolated by vacuum filtration

Sources & evidence

ORD record
ord-e6e9ab01392d49399bd1683021df6882
Source dataset
uspto-grants-1988_05
Patent number
US04742061

Reaction notes

Loading…