反应详情

A mixture of 1-(p-nitrobenzyloxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine (14.78 g) in acetone (222 ml) and sodium iodide (12.71 g) was refluxed for 23 hours. The reaction mixture was filtered and the filtrate was evaporated to dryness. The residue was diluted with ethyl acetate and the extract was washed successively with aqueous 10% sodium sulfite and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and evaporated to give 1-(p-nitrobenzyloxycarbonyl)-4-iodopiperidine.

1. temperaturewas refluxed for 23 hours
2. filtrationThe reaction mixture was filtered
3. customthe filtrate was evaporated to dryness
4. additionThe residue was diluted with ethyl acetate
5. washthe extract was washed successively with aqueous 10% sodium sulfite and saturated aqueous sodium chloride
6. dry with materialdried over anhydrous sodium sulfate
7. customevaporated