HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 5-[(Ethylsulfamoyl)acetyl]-1,4-dihydro-2-methyl-4-(3-nitrophenyl)nicotinic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 3-Nitrobenzylideneacetoacetic acid methyl ester | HCID 53443010 | — |
| Reactant | N-ethyl-4-amino-2-oxo-3-butenesulfonamide | HCID 73663801 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-[(Ethylsulfamoyl)acetyl]-1,4-dihydro-2-methyl-4-(3-nitrophenyl)nicotinic acid methyl ester | HCID 70416500 | — |
Reaction Steps
After boiling 2.5 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 1.92 g of N-ethyl-4-amino-2-oxo-3-butenesulfonamide in a mixture of 10 ml of isopropanol and 5 ml of dimethylformamide for 6 hours there were obtained 2.2 g of 5-[(ethylsulfamoyl)acetyl]-1,4-dihydro-2-methyl-4-(3-nitrophenyl)nicotinic acid methyl ester of melting point 185°-187° (yellow crystalline powder from acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04742069 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-b712a5aa9ead467485ffa3be7f6cfa1c |
| Source note | uspto-grants-1988_05 |