Methylamine → HCID 86742152, compound

HRID 1252257Notes

Reaction equation

HRID 1252257 reaction equation
[CH3:1][NH2:2].[CH:3]([N:6]1[C:11]([CH3:12])=[CH:10][C:9](=[O:13])[CH2:8][S:7]1(=[O:15])=[O:14])([CH3:5])[CH3:4]>CO>[CH:3]([NH:6][S:7]([CH2:8][C:9](=[O:13])[CH:10]=[C:11]([NH:2][CH3:1])[CH3:12])(=[O:15])=[O:14])([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 12470829HCID 12470829, compound

Product 1

HCID 86742152HCID 86742152, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A slow stream of dry methylamine was introduced at 20°-25° during 1 hour into a suspension of 4 g of 2-isopropyl-3-methyl-1,2-thiazin-5(6H)-one 1,1-dioxide in 40 ml of methanol, whereby a clear yellow solution resulted after about 30 minutes. Thereupon, the mixture was stirred further at room temperature for 5 hours, concentrated to dryness under reduced pressure and the crystalline residue was recrystallized from isopropyl. There were obtained 3.8 g of N-isopropyl-4-methylamino-2-oxo-3-pentenesulfonamide in the form of colorless crystals, m.p. 83°-85°.

Workup

  1. customresulted after about 30 minutes
  2. concentrationconcentrated to dryness under reduced pressure
  3. customthe crystalline residue was recrystallized from isopropyl

Sources & evidence

ORD record
ord-4c2bc66c9dde4cd780833c59c993bb31
Source dataset
uspto-grants-1988_05
Patent number
US04742069

Reaction notes

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