Hydrochloric Acid → 1-Ethylpiperidine-2,4-dione

HRID 1252280Notes

Reaction equation

HRID 1252280 reaction equation
Cl.C([CH:7]1[C:12](=[O:13])[CH2:11][CH2:10][N:9]([CH2:14][CH3:15])[C:8]1=[O:16])(OCC)=O>>[CH2:14]([N:9]1[CH2:10][CH2:11][C:12](=[O:13])[CH2:7][C:8]1=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13784118Ethyl 1-Ethyl-2,4-dioxopiperidine-3-carboxylate

Product 1

HCID 137841191-Ethylpiperidine-2,4-dioneYield 70%

Procedure

300 ml of a 10% aqueous hydrochloric acid solution was added to 36.0 g of 3-carboethoxy-1-ethylpiperidine-2,4-dione, and they were refluxed for 40 minutes and allowed to cool. The resulting mixture was subjected to extraction by chloroform. The resulting chloroform layer was water-washed, dried and concentrated to obtain 16.6 g of 1-ethylpiperidine-2,4-dione as a light yellow oily matter with an yield of 70%.

Workup

  1. temperaturewere refluxed for 40 minutes
  2. temperatureto cool
  3. extractionThe resulting mixture was subjected to extraction by chloroform
  4. washwashed
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-d771d3da6787491b8bf5542e59473806
Source dataset
uspto-grants-1988_05
Patent number
US04742165

Reaction notes

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