Ammonium Hydroxide → 2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-sulfonamide

Participants

Reaction Steps

A solution of 0.5 gram (0.002 mole) of 7-chlorosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran and 4 ml of tetrahydrofuran was stirred and 2 ml of an aqueous solution of 29% ammonium hydroxide was added. The reaction mixture stirred for one hour, then was concentrated under reduced pressure to a residue. The residue was triturated with water and filtered to collect, when dried, 0.41 grams of 7-aminosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran; m.p. 160.5°-162.5° C.

Provenance & Evidence