Ammonium Hydroxide → 2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-sulfonamide

HRID 1252341Notes

Reaction equation

HRID 1252341 reaction equation
Cl[S:2]([C:5]1[C:13]2[O:12][C:11]([CH3:15])([CH3:14])[CH2:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)(=[O:4])=[O:3].[OH-].[NH4+:17]>O1CCCC1>[NH2:17][S:2]([C:5]1[C:13]2[O:12][C:11]([CH3:15])([CH3:14])[CH2:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 134241792,2-Dimethyl-2,3-dihydro-1-benzofuran-7-sulfonyl chloride

Product 1

HCID 134241802,2-Dimethyl-2,3-dihydro-1-benzofuran-7-sulfonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.5 gram (0.002 mole) of 7-chlorosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran and 4 ml of tetrahydrofuran was stirred and 2 ml of an aqueous solution of 29% ammonium hydroxide was added. The reaction mixture stirred for one hour, then was concentrated under reduced pressure to a residue. The residue was triturated with water and filtered to collect, when dried, 0.41 grams of 7-aminosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran; m.p. 160.5°-162.5° C.

Workup

  1. concentrationwas concentrated under reduced pressure to a residue
  2. customThe residue was triturated with water
  3. filtrationfiltered
  4. customto collect
  5. customwhen dried

Sources & evidence

ORD record
ord-92e4df03ef304ea09130b8c314d3c4eb
Source dataset
uspto-grants-1988_05
Patent number
US04743291

Reaction notes

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