HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 2,2-Dimethyl-2,3-dihydro-1-benzofuran-5-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2,2-Dimethyl-2,3-dihydro-1-benzofuran-5-sulfonyl chloride | HCID 15611038 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,2-Dimethyl-2,3-dihydro-1-benzofuran-5-sulfonamide | HCID 15611039 | — |
Reaction Steps
In a manner similar to Step B of Example 9, the reaction of 9.0 g (0.036 mole) of 5-chlorosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran with 60 mL of an aqueous 29% ammonium hydroxide solution in 70 mL of tetrahydrofuran produced 8.0 g of 5-aminosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran as a solid (mp 157°-160° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04743291 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-5ac40133dcb2410cb21019c66271bbc9 |
| Source note | uspto-grants-1988_05 |