Ammonium Hydroxide → 2,2-Dimethyl-2,3-dihydro-1-benzofuran-5-sulfonamide

HRID 1252345Notes

Reaction equation

HRID 1252345 reaction equation
Cl[S:2]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=2[CH:15]=1)(=[O:4])=[O:3].[OH-].[NH4+:17]>O1CCCC1>[NH2:17][S:2]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=2[CH:15]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 156110382,2-Dimethyl-2,3-dihydro-1-benzofuran-5-sulfonyl chloride

Product 1

HCID 156110392,2-Dimethyl-2,3-dihydro-1-benzofuran-5-sulfonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to Step B of Example 9, the reaction of 9.0 g (0.036 mole) of 5-chlorosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran with 60 mL of an aqueous 29% ammonium hydroxide solution in 70 mL of tetrahydrofuran produced 8.0 g of 5-aminosulfonyl-2,3-dihydro-2,2-dimethylbenzofuran as a solid (mp 157°-160° C.).

Sources & evidence

ORD record
ord-5ac40133dcb2410cb21019c66271bbc9
Source dataset
uspto-grants-1988_05
Patent number
US04743291

Reaction notes

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