Trifluoroacetic acid → HCID 14254946, compound

HRID 1252358Notes

Reaction equation

HRID 1252358 reaction equation
[CH2:1]([S:4]([C:6]1[C:7]([S:15]([NH:18]C(C)(C)C)(=[O:17])=[O:16])=[C:8]([C:11]([O:13][CH3:14])=[O:12])[S:9][CH:10]=1)=[O:5])[CH2:2][CH3:3].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([S:4]([C:6]1[C:7]([S:15]([NH2:18])(=[O:17])=[O:16])=[C:8]([C:11]([O:13][CH3:14])=[O:12])[S:9][CH:10]=1)=[O:5])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14254945HCID 14254945, compound

Product 1

HCID 14254946HCID 14254946, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2.2 g of 4-propylsulfinyl-3-(N-(1,1-dimethylethyl)aminosulfonyl)-2-thiophenecarboxylic acid, methyl ester in 15 mL methylene chloride was treated with 30 mL trifluoroacetic acid at room temperature for 24 hours. The solvent were removed in vacuo and the residue was crystallized with butyl chloride to give 1.74 g white solid; m.p. 131°-144° C.

Workup

  1. customThe solvent were removed in vacuo
  2. customthe residue was crystallized with butyl chloride

Sources & evidence

ORD record
ord-ec8ca7ad185c44cc99381f3ab45d4744
Source dataset
uspto-grants-1988_05
Patent number
US04743290

Reaction notes

Loading…