反应详情

温度

-10 °C

A solution of 16 g of 2,3-dioxobutyric acid ethyl ester, (Z)-2-oxime, 12 g of 3-aminomethylpyridine and 100 ml of acetonitrile was stirred at reflux for 4 hours, then clarified while hot and the filtrate cooled at -10° C. The resulting precipitate was collected, washed with acetonitrile, air dried and recrystallized from acetonitrile at -10° C., giving 4.8 g of 5-methyl-2-(3-pyridinyl)-1H-imidazole-4-carboxylic acid, ethyl ester.

1. temperatureat reflux for 4 hours
2. customThe resulting precipitate was collected
3. washwashed with acetonitrile, air
4. customdried
5. customrecrystallized from acetonitrile at -10° C.