HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1252368Generated: October 26, 2026
Acetonitrile → 5-Methyl-2-pyridin-3-YL-3H-imidazole-4-carboxylic acid ethyl ester
https://huagongshe.com/reaction/1252368
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 3-Pyridinemethanamine | HCID 31018 | — |
| Reactant | Ethyl 2,3-dioxobutanoate | HCID 12260829 | — |
| Product | 5-Methyl-2-pyridin-3-YL-3H-imidazole-4-carboxylic acid ethyl ester | HCID 53435874 | — |
Reaction Steps
A solution of 16 g of 2,3-dioxobutyric acid ethyl ester, (Z)-2-oxime, 12 g of 3-aminomethylpyridine and 100 ml of acetonitrile was stirred at reflux for 4 hours, then clarified while hot and the filtrate cooled at -10° C. The resulting precipitate was collected, washed with acetonitrile, air dried and recrystallized from acetonitrile at -10° C., giving 4.8 g of 5-methyl-2-(3-pyridinyl)-1H-imidazole-4-carboxylic acid, ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04743586 |
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| Source dataset | uspto-grants-1988_05 |
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| ORD ID | ord-f1e427162e704b248f2999ec89e0e348 |
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| Source note | uspto-grants-1988_05 |
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