反应详情

Ethyl 2-(5-t-butylthiophen-2-yl)-cyclopropanecarboxylate (4.49 g, 0.018 mol) was dissolved in methanol (45 ml) and a solution of potassium hydroxide (1.99 g, 0.036 mol) in water (45 ml) added dropwise at room temperature. The solution was refluxed for 3 hours, cooled to room temperature and carefully neutralised with 2M HCl. Saturated sodium chloride was added, the aqueous solution extracted with ethyl acetate (4×50 ml) and dried over anhydrous sodium sulphate. Removal of the solvent gave 2-(5-t-butylthiophen-2-yl)-cyclopropanecarboxylic acid (3.79 g, 94%).

1. temperatureThe solution was refluxed for 3 hours
2. extractionthe aqueous solution extracted with ethyl acetate (4×50 ml)
3. dry with materialdried over anhydrous sodium sulphate
4. customRemoval of the solvent