反应详情

A mixture of 2-(5-t-butylthiophen-2-yl)-cyclopropanecarboxylic acid (3.38 g, 0.015 mol) and oxalyl chloride (2.65 g, 0.021 mol) in hexane (35 ml) was stirred at room temperature for 2 hours and then warmed at 60° C. for 3 hours. The hexane and excess oxalyl chloride were removed in vacuo to give 2-(5-t-butylthiophen-2-yl)-cyclopropanecarbonyl chloride (3.59 g, 99%) as a pale yellow liquid which was used in the next stage without further purification.

1. temperaturewarmed at 60° C. for 3 hours
2. customThe hexane and excess oxalyl chloride were removed in vacuo