Dimethylformamide → 6-Methoxy-5-(trifluoromethyl)naphthalen-1-amine

Temperature

0 °C

6-Methoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic acid (30.0 g, 1.11×10-1M) was stirred in thionyl chloride (120 mL) at 20° C. under nitrogen. Dimethylformamide (0.75 mL, anhydrous) was added, and the mixture was refluxed for 4 hours. The solvent and excess of thionyl chloride were evaporated under reduced pressure. Toluene (200 mL) was added, the solvent re-evaporated and the residual solid was dried (20° C./0.1 mm). The white solid was dissolved in acetone (300 mL), cooled to 0° C. and a solution of sodium azide (7.8 g, 1.19×10-1M) in water (25 mL) was added dropwise (precipitate formation). The mixture was stirred at 0° C. for 30 minutes, diluted to 600 mL volume with water, stirred for 1 hour at 0° C., filtered, and the filtered solid was washed with water (2×200 mL). The damp solid (Any azides are generally unsafe to handle.) was dissolved in toluene (400 mL), and the filtrate concentrated to 280 mL under reduced pressure, refluxed for 1 hour, then cooled to 20° C. Potassium hydroxide (40% aq, 200 mL) was added. The resultant mixture was refluxed for 1 hour, cooled to 30° C., and filtered. The filtered solid (This solid is an unwanted side product. Care should be taken to avoid precipitation of the desired product from toluene during filtration.) was washed with water (200 mL), and toluene (200 mL). The filtrate and washings were combined. The organic layer was separated, washed with water (200 mL), dried (MgSO4), filtered, and solvent evaporated to furnish the product (19.0 g, 84%) m.p. 120° C. as a white powder.

1. temperaturethe mixture was refluxed for 4 hours
2. customThe solvent and excess of thionyl chloride were evaporated under reduced pressure
3. additionToluene (200 mL) was added
4. customthe solvent re-evaporated
5. customthe residual solid was dried (20° C./0.1 mm)
6. dissolutionThe white solid was dissolved in acetone (300 mL)
7. additiona solution of sodium azide (7.8 g, 1.19×10-1M) in water (25 mL) was added dropwise (precipitate formation)
8. additiondiluted to 600 mL volume with water
9. stirringstirred for 1 hour at 0° C.
10. filtrationfiltered
11. washthe filtered solid was washed with water (2×200 mL)
12. dissolution) was dissolved in toluene (400 mL)
13. concentrationthe filtrate concentrated to 280 mL under reduced pressure
14. temperaturerefluxed for 1 hour
15. temperaturecooled to 20° C
16. additionPotassium hydroxide (40% aq, 200 mL) was added
17. temperatureThe resultant mixture was refluxed for 1 hour
18. temperaturecooled to 30° C.
19. filtrationfiltered
20. customprecipitation of the desired product from toluene
21. filtrationduring filtration
22. wash) was washed with water (200 mL), and toluene (200 mL)
23. customThe organic layer was separated
24. washwashed with water (200 mL)
25. dry with materialdried (MgSO4)
26. filtrationfiltered
27. customsolvent evaporated

ORD record

ord-d055c9f10a084bf690a86f35aa47a035

Source dataset

uspto-grants-1988_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04743611