反应详情

To a solution of 2-[(5-methyl-4-piperidino-2-pyridyl)methylthio]indole (80 mg, 0.24 mmol) in chloroform (2.4 ml) was added m-chloroperbenzoic acid (60 mg, 0.35 mmol) under ice-cooling, and the mixture was stirred at that temperature for further 30 minutes. The reaction solution was diluted with chloroform (10 ml) and then washed with a 1% aqueous sodium hydrogen carbonate solution (2.5 ml) and then with a saturated aqueous sodium chloride solution (1 ml). The resulting chloroform layer was dried over anhydrous magnesium sulfate and then concentrated in vacuo. Ethylether (20 ml) was added to the resulting concentration residue to precipitate crystals. After filtration, the titled compound (68 mg) was obtained. Yield: 81%, m.p.: 178° C.

1. temperaturecooling
2. washwashed with a 1% aqueous sodium hydrogen carbonate solution (2.5 ml)
3. dry with materialThe resulting chloroform layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated in vacuo
5. additionEthylether (20 ml) was added to the resulting concentration residue
6. customto precipitate crystals
7. filtrationAfter filtration