4-(5-Bromo-3-methyl-2-pyridinyl)butylamine → HCID 178422460, compound

HRID 1252537Notes

Reaction equation

HRID 1252537 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:6][CH:7]=1.CS[C:16]1[C:20]2[S:21][CH:22]=[CH:23][C:19]=2[S:18](=[O:25])(=[O:24])[N:17]=1>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:16]2[C:20]3[S:21][CH:22]=[CH:23][C:19]=3[S:18](=[O:25])(=[O:24])[N:17]=2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 130942724-(5-Bromo-3-methyl-2-pyridinyl)butylamineHCID 14086552HCID 14086552, compound

Product 1

HCID 178422460HCID 178422460, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.514 g (0.0021 mole) of 4-(5-bromo-3-methyl-2-pyridinyl)butylamine and 0.463 g (0.0021 mole) of 3-(methylthio)thieno[2,3-d]isothiazole 1,1-dioxide in 35 ml of ethanol was heated under reflux with stirring for 4 hours. The reaction solution was cooled in ice giving a crystalline product which amounted to 0.71 g, m.p. 191°-193° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperatureThe reaction solution was cooled in ice giving a crystalline product which

Sources & evidence

ORD record
ord-5d72514672d84616b01d394895aa8a30
Source dataset
uspto-grants-1988_05
Patent number
US04743692

Reaction notes

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