4-(5-Bromo-3-methyl-2-pyridinyl)butylamine → HCID 178422455, compound

HRID 1252541Notes

Reaction equation

HRID 1252541 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:6][CH:7]=1.[Br:14][C:15]1[CH:26]=[CH:25][C:18]2[C:19](Cl)=[N:20][S:21](=[O:23])(=[O:22])[C:17]=2[CH:16]=1>C(#N)C>[Br:14][C:15]1[CH:26]=[CH:25][C:18]2[C:19]([NH:12][CH2:11][CH2:10][CH2:9][CH2:8][C:5]3[C:4]([CH3:13])=[CH:3][C:2]([Br:1])=[CH:7][N:6]=3)=[N:20][S:21](=[O:23])(=[O:22])[C:17]=2[CH:16]=1

Participants

4

Reactant 2

HCID 130942724-(5-Bromo-3-methyl-2-pyridinyl)butylamineHCID 1415429987476-69-5

Product 1

HCID 178422455HCID 178422455, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A slurry of 4-(5-bromo-3-methyl-2-pyridinyl)butylamine (252 mg, 1.04 mmol) and 6-bromo-3-chlorobenzisothiazole 1,1-dioxide (U.S. Pat. No. 4,490,527) (292 mg, 1.04 mmol) in 15 ml acetonitrile was heated under dry nitrogen until nearly completely dissolved, when the above compound precipitated as the hydrochloride salt, yielding 360 mg (66%), m.p. 224°-232° C. IR(KBr) 1620, 1300, 1160, 650 cm-1.

Workup

  1. dissolutionuntil nearly completely dissolved
  2. customwhen the above compound precipitated as the hydrochloride salt
  3. customyielding 360 mg (66%), m.p. 224°-232° C

Sources & evidence

ORD record
ord-777d15afcd304d3ea73ef0af1cbb43ad
Source dataset
uspto-grants-1988_05
Patent number
US04743692

Reaction notes

Loading…