Ethyl 6-Phenyl-5-p-tolyl-pyridine-2-carboxylate → Methyl 6-phenyl-5-(p-tolyl)picolinate

HRID 12526Notes

Reaction equation

HRID 12526 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]([C:13]([O:15][CH2:16]C)=[O:14])[CH:10]=[CH:9][C:8]=2[C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>OS(O)(=O)=O.CO>[C:1]1([C:7]2[N:12]=[C:11]([C:13]([O:15][CH3:16])=[O:14])[CH:10]=[CH:9][C:8]=2[C:18]2[CH:19]=[CH:20][C:21]([CH3:24])=[CH:22][CH:23]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 25033077Ethyl 6-Phenyl-5-p-tolyl-pyridine-2-carboxylate2×

Product 1

HCID 25033163Methyl 6-phenyl-5-(p-tolyl)picolinate

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolvent

Procedure

Following General Procedure E, ethyl 6-phenyl-5-p-tolyl-pyridine-2-carboxylate (Compound 22, 70 mg, 0.22 mmol) and conc. H2SO4 (3 drops) in MeOH (3 ml) were reacted to produce the title compound as a yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3bbe9e8d5be141679a7e56b70fc93128
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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