反应详情

To a suspension of 2.0 g (6 mmol) of 2-(chloromethyl)-5-(phenylmethoxy)-1-(phenylmethyl)-4(1H)-pyridinone in 20 ml of acetonitrile was added 3.9 g (60 mmol) of sodium azide and 0.1 g of 18-crown-6, and the mixture was heated to reflux for four hours. The salts were filtered off by suction, and the filtrate was evaporated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate-methanol 8:2) yielding 1.86 g of the title compound, melting point 120° C.

1. temperaturethe mixture was heated
2. temperatureto reflux for four hours
3. filtrationThe salts were filtered off by suction
4. customthe filtrate was evaporated in vacuo
5. customThe residue was purified by column chromatography on silica gel (ethyl acetate-methanol 8:2)