Diethyl Ether → HCID 131715531, compound

HRID 1252634Notes

Reaction equation

HRID 1252634 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:12][CH2:13][CH2:14][NH:15][C:16]([C:18]1[NH:19][CH:20]=[C:21]([OH:25])[C:22](=[O:24])[CH:23]=1)=[O:17].C(O)=O.[ClH:29].CCOCC>C(O)=O>[ClH:29].[ClH:29].[NH2:12][CH2:13][CH2:14][NH:15][C:16]([C:18]1[NH:19][CH:20]=[C:21]([OH:25])[C:22](=[O:24])[CH:23]=1)=[O:17]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 14182525HCID 14182525, compoundHCID 23505578HCID 23505578, compound

Product 1

HCID 131715531HCID 131715531, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

N-(2-Aminoethyl)-1,4-dihydro-5-hydroxy-4-oxo-2-pyridinecarboxamide, p-toluenesulfonate salt (5.42 g) was dissolved in 50 ml of formic acid and 7.5 ml of formic acid/hydrochloric acid gas (2.2 equivalents hydrochloric acid) was added followed by 150 ml of ether; white crystals of were obtained. Isolation by filtration and washing with 200 ml of ether yielded 2.60 g of the title compound, melting point 287° C.

Workup

  1. customwhite crystals of were obtained
  2. filtrationIsolation by filtration
  3. washwashing with 200 ml of ether

Sources & evidence

ORD record
ord-6f80caaaed97424c8520529b6e9c59b1
Source dataset
uspto-grants-1988_05
Patent number
US04743685

Reaction notes

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