Diethyl Ether → HCID 131715531, compound

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Reaction Steps

N-(2-Aminoethyl)-1,4-dihydro-5-hydroxy-4-oxo-2-pyridinecarboxamide, p-toluenesulfonate salt (5.42 g) was dissolved in 50 ml of formic acid and 7.5 ml of formic acid/hydrochloric acid gas (2.2 equivalents hydrochloric acid) was added followed by 150 ml of ether; white crystals of were obtained. Isolation by filtration and washing with 200 ml of ether yielded 2.60 g of the title compound, melting point 287° C.

Provenance & Evidence