反应详情

In 200 ml of methylene chloride were dissolved 38 g of 1,2-propanediol and 44 g of pyridine and, then, 95 g of p-toluenesulfonyl chloride was added gradually over a period of 15 minutes. The reaction was further conducted at room temperature for 72 hours. The reaction mixture was washed twice with one volume of water each, dehydrated over anhydrous sodium sulfate, and concentrated under reduced pressure. The concentrate was crystallized from toluene-hexane (100 ml-100 ml), filtered, and dried in vacuo to give colorless crystals of (RS)-1-p-toluenesulfonyloxy-2-propanol 2a ##STR21## (54 g).

1. washThe reaction mixture was washed twice with one volume of water each,
2. concentrationconcentrated under reduced pressure
3. customThe concentrate was crystallized from toluene-hexane (100 ml-100 ml)
4. filtrationfiltered
5. customdried in vacuo