HCID 13590429, compound → HCID 13590431, compound

HRID 1252695Notes

Reaction equation

HRID 1252695 reaction equation
[CH2:1]1[O:19][CH:4]([C:5]2[CH:10]=[CH:9][C:8](/[CH:11]=[CH:12]/[C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:7][CH:6]=2)[O:3][CH2:2]1>C(O)C.[Pd]>[CH2:2]1[O:3][CH:4]([C:5]2[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[CH:7][CH:6]=2)[O:19][CH2:1]1

Participants

4

Reactant 1

HCID 13590429HCID 13590429, compound

Product 1

HCID 13590431HCID 13590431, compoundYield 85.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10 g (39.5 mmol) of E-4-[2-(3-pyridyl)ethenyl]benzaldehyde ethylene acetal (1a) were dissolved in 100 ml of ethanol, 1.6 g of palladium on charcoal (10%) were added, and hydrogenation was carried out at room temperature and under atmospheric pressure. Filtration and removal of the solvent in vacuo produced 8.6 g (33.7 mmol, 85%) of a white solid.

Workup

  1. customwas carried out at room temperature and under atmospheric pressure
  2. filtrationFiltration and removal of the solvent in vacuo

Sources & evidence

ORD record
ord-74305957087c4a8f82666cba52c610b9
Source dataset
uspto-grants-1988_05
Patent number
US04745120

Reaction notes

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