Ethyl 5-(4-ethylphenyl)-6-phenylpyridine-2-carboxylate → Methyl 5-(4-Ethylphenyl)-6-phenyl-pyridine-2-carboxylate

HRID 12527Notes

Reaction equation

HRID 12527 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:21]([O:23][CH2:24]C)=[O:22])=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][CH:4]=1)[CH3:2]>OS(O)(=O)=O.CO>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:21]([O:23][CH3:24])=[O:22])=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 25033078Ethyl 5-(4-ethylphenyl)-6-phenylpyridine-2-carboxylate2×

Product 1

HCID 25033164Methyl 5-(4-Ethylphenyl)-6-phenyl-pyridine-2-carboxylate

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolvent

Procedure

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-phenylpyridine-2-carboxylate (Compound 23, 45 mg, 0.15 mmol) and conc. H2SO4 (3 drops) in MeOH (3 ml) were reacted to produce title compound as a yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c8f862b8d57b4ed5a6bad16f2966582d
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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