Potassium Carbonate → HCID 20139157, compound

HRID 1252738Notes

Reaction equation

HRID 1252738 reaction equation
Cl.[NH2:2][C:3]1[CH:16]=[CH:15][C:6]2[C:7](=[O:14])[O:8][C:9]([O:11][CH2:12][CH3:13])=[N:10][C:5]=2[CH:4]=1.[C:17](=O)([O-])[O-].[K+].[K+]>CCOCC>[NH2:2][C:3]1[CH:16]=[C:15]([CH3:17])[C:6]2[C:7](=[O:14])[O:8][C:9]([O:11][CH2:12][CH3:13])=[N:10][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 20139188HCID 20139188, compound

Product 1

HCID 20139157HCID 20139157, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 7-amino-2-ethoxy-4H-3,1-benzoxazin-4-one HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 7-amino-2-ethoxy-5-methyl-4H-3,1-benzoxazin-4-one as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-5c82c3759a75430a89d4bfcc5f755a36
Source dataset
uspto-grants-1988_05
Patent number
US04745116

Reaction notes

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