Water → HCID 13491012, compound

HRID 1252778Notes

Reaction equation

HRID 1252778 reaction equation
[CH3:1][NH:2][C:3](=[O:10])[C@H:4]([CH2:6][CH2:7][S:8][CH3:9])[NH2:5].CCCCC.O.[CH:17](=O)[C:18]([CH3:21])([CH3:20])[CH3:19]>>[CH3:1][NH:2][C:3](=[O:10])[C@H:4]([CH2:6][CH2:7][S:8][CH3:9])[N:5]=[CH:17][C:18]([CH3:21])([CH3:20])[CH3:19]

Participants

5

Reactant 4

HCID 962Water2×HCID 8003PentaneHCID 12417PivalaldehydeHCID 13491009HCID 13491009, compound

Product 1

HCID 13491012HCID 13491012, compound

Procedure

There were added to 40.0 grams (247 mmoles) of (S)-methionine mono-methylamide dissolved in 100 ml of n-pentane 27.5 ml (250 mmoles) of pivalaldehyde. The reaction mixture was boiled on the water separator until the formation of water ended (3 hours). The solvent was removed under reduced pressure and there remained behind 52.2 grams (92% of theory) of (S)-N-(2', 2'- dimethylpropylidene)-methionine mono-methylamide which was further processed without further purification.

Workup

  1. custom(3 hours)
  2. customThe solvent was removed under reduced pressure
  3. customwas further processed without further purification

Sources & evidence

ORD record
ord-f72335786f0043679f8e1f04b460dca1
Source dataset
uspto-grants-1988_05
Patent number
US04745218

Reaction notes

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