反应详情

N-(3-Acetylthio-2-trifluoromethylpropanoyl)-L-proline (4 g) is dissolved in a mixture of water (8 ml) and concentrated ammonia (8 ml) under a blanket of nitrogen. After twenty-five minutes stirring at room temperature, the reaction mixture is chilled, acidified and extracted with ethyl acetate. The organic layer is concentrated to dryness in vacuo to yield N-(3-mercapto-2-trifluoromethylpropanoyl)-L-proline.

1. temperaturethe reaction mixture is chilled
2. extractionextracted with ethyl acetate
3. concentrationThe organic layer is concentrated to dryness in vacuo