1-(3-acetylthio-2-trifluoromethylpropanoyl)-L-proline → 1-(3-mercapto-2-trifluoromethylpropanoyl)-L-proline

Participants

Reaction Steps

N-(3-Acetylthio-2-trifluoromethylpropanoyl)-L-proline (4 g) is dissolved in a mixture of water (8 ml) and concentrated ammonia (8 ml) under a blanket of nitrogen. After twenty-five minutes stirring at room temperature, the reaction mixture is chilled, acidified and extracted with ethyl acetate. The organic layer is concentrated to dryness in vacuo to yield N-(3-mercapto-2-trifluoromethylpropanoyl)-L-proline.

Provenance & Evidence