HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → HCID 20130635, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydrothien-3-yl]ureido}-benzoate | HCID 20130628 | — |
| Solvent | Isopropanol dimethylformamide | HCID 20197112 | — |
| Product | HCID 20130635 | HCID 20130635 | — |
Reaction Steps
using isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydrothien-3-yl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-{1,2,5,7-tetrahydro-2,4-dioxothieno[3,4-d]pyrimidin-3(4H)-yl}-benzoate, m.p. 180°-183° C.,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04746352 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-752a7210352d437fa748d5e9e6ff3e4c |
| Source note | uspto-grants-1988_05 |